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KMID : 0387420170280040359
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Korean Society of Oriental Neuropsychiatry
2017 Volume.28 No. 4 p.359 ~ p.371
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The Effect of Oral Administration of Herbal Medicines on Memory in Alzheimer's Disease Animal Models: A Review of Animal Study Reports Published in Korea
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Han Da-Young
Park Na-Eun
Kim Sang-Ho
Chung Dae-Kyoo
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Abstract
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Objectives: The objective of this study was to review the effect of oral administration of herbal medi-cines on the improvement of memory in Alzheimer's disease animal model reported in Korean domes-tic journals.
Methods: The Korean databases (Koreantk, KISS) were searched with memory as a popular search term. During the searches, only animal study reports were reviewed. Data of animal models, intervention, observation methods of measuring indicators were extracted from the databases.
Results: Typically, 36 articles were reviewed. Twenty-two studies used scopolamine to induce Alzheimer's disease, 24 studies used complex herbal medicines, and 12 studies used simple herbal medicines. Polygalae Radix and Acori Rhizoma were the most frequently used herbal medicines to im-prove memory in Alzheimer model. To evaluate the effect of herbal medicines, 36 studies used macro-scopy, 16 studies used molecular biological analysis, 21 studies used biochemical analysis, 15 studies used histological analysis, and 11 studies used hematological analysis. Each study showed significant improvement with respect to memory indicators.
Conclusions: Overall, the results suggest that treatment employing herbal medicines is an effective op-tion to treat memory impairment in Alzheimer’s disease.
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KEYWORD
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Alzheimer's disease, Memory, Herbal medicine, Animal model, Review
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